Regulatory T cells, tumour immunity and immunotherapy.

Authors:
Weiping Zou

Nat Rev Immunol 2006 Apr;6(4):295-307

Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0346, USA.

Tumours express a range of antigens, including self-antigens. Regulatory T cells are crucial for maintaining T-cell tolerance to self-antigens. Regulatory T cells are thought to dampen T-cell immunity to tumour-associated antigens and to be the main obstacle tempering successful immunotherapy and active vaccination. In this Review, I consider the nature and characteristics of regulatory T cells in the tumour microenvironment and their potential multiple suppressive mechanisms. Strategies for therapeutic targeting of regulatory T cells and the effect of regulatory T cells on current immunotherapeutic and vaccine regimens are discussed.

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http://dx.doi.org/10.1038/nri1806DOI Listing
April 2006
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