Genetic determinants of cancer metastasis.

Nat Rev Genet 2007 May;8(5):341-52

Cancer Biology and Genetics Program, and Howard Hughes Medical Institute, Box 116, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10021, USA.

Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare tumour cells that overcame stringent physiological barriers as they separated from their original environment and developmental fate. This phenomenon brings into focus long-standing questions about the stage at which cancer cells acquire metastatic abilities, the relationship of metastatic cells to their tumour of origin, the basis for metastatic tissue tropism, the nature of metastasis predisposition factors and, importantly, the identity of genes that mediate these processes. With knowledge cemented in decades of research into tumour-initiating events, current experimental and conceptual models are beginning to address the genetic basis for cancer colonization of distant organs.

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May 2007
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References

(Supplied by CrossRef)

B Weigelt et al.
Nature Rev. Cancer 2005

AJ van de Wouw et al.
Ann. Oncol. 2003

L Weiss et al.
Cancer Metastasis Rev. 2000

L Norton et al.
Nature Med. 2006

D Hanahan et al.
Cell 2000

G Christofori et al.
Nature 2006

IJ Fidler et al.
Nature Rev. Cancer 2003

GP Gupta et al.
Cell 2006

GR Mundy et al.
Nature Rev. Cancer 2002

PS Steeg et al.
Nature Med. 2006

LL Capasso et al.
Int. J. Cancer 2005

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