Epidemiology and risk profile of heart failure.

Nat Rev Cardiol 2011 Jan 9;8(1):30-41. Epub 2010 Nov 9.

Ahmanson-UCLA Cardiomyopathy Center, UCLA Medical Center, 10833 Le Conte Avenue, Room 47-123 CHS, Los Angeles, CA 90095-1679, USA.

Heart failure (HF) is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing HF is one in five. Although promising evidence shows that the age-adjusted incidence of HF may have plateaued, HF still carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. HF represents a considerable burden to the health-care system, responsible for costs of more than $39 billion annually in the USA alone, and high rates of hospitalizations, readmissions, and outpatient visits. HF is not a single entity, but a clinical syndrome that may have different characteristics depending on age, sex, race or ethnicity, left ventricular ejection fraction (LVEF) status, and HF etiology. Furthermore, pathophysiological differences are observed among patients diagnosed with HF and reduced LVEF compared with HF and preserved LVEF, which are beginning to be better appreciated in epidemiological studies. A number of risk factors, such as ischemic heart disease, hypertension, smoking, obesity, and diabetes, among others, have been identified that both predict the incidence of HF as well as its severity. In this Review, we discuss key features of the epidemiology and risk profile of HF.

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http://dx.doi.org/10.1038/nrcardio.2010.165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033496PMC
January 2011
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References

(Supplied by CrossRef)

D Lloyd-Jones et al.
Circulation 2010

JJ McMurray et al.
Eur. Heart J. 1998

D Levy et al.
N. Engl. J. Med. 2002

DD Schocken et al.
J. Am. Coll. Cardiol. 1992

J Fang et al.
J. Am. Coll. Cardiol. 2008

AW Hoes et al.
Eur. Heart J. 1998

PA McCullough et al.
J. Am. Coll. Cardiol. 2002

JB Croft et al.
Arch. Intern. Med. 1999

MW Rich et al.
J. Gerontol. A Biol. Sci. Med. Sci. 2001

WH Barker et al.
Circulation 2006

LR Loehr et al.
Am. J. Cardiol. 2008

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