The immunology of stroke: from mechanisms to translation.

Nat Med 2011 Jul 7;17(7):796-808. Epub 2011 Jul 7.

Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York, USA.

Immunity and inflammation are key elements of the pathobiology of stroke, a devastating illness second only to cardiac ischemia as a cause of death worldwide. The immune system participates in the brain damage produced by ischemia, and the damaged brain, in turn, exerts an immunosuppressive effect that promotes fatal infections that threaten the survival of people after stroke. Inflammatory signaling is involved in all stages of the ischemic cascade, from the early damaging events triggered by arterial occlusion to the late regenerative processes underlying post-ischemic tissue repair. Recent developments have revealed that stroke engages both innate and adaptive immunity. But adaptive immunity triggered by newly exposed brain antigens does not have an impact on the acute phase of the damage. Nevertheless, modulation of adaptive immunity exerts a remarkable protective effect on the ischemic brain and offers the prospect of new stroke therapies. As immunomodulation is not devoid of deleterious side effects, a better understanding of the reciprocal interaction between the immune system and the ischemic brain is essential to harness the full therapeutic potential of the immunology of stroke.

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http://dx.doi.org/10.1038/nm.2399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137275PMC
July 2011
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References

(Supplied by CrossRef)

H Mena et al.
Acta Neuropathol. 2004

MA Moskowitz et al.
Neuron 2010

C Meisel et al.
Nat. Rev. Neurosci. 2005

X Urra et al.
Neuroscience 2009

HL Weiner et al.
Ann. Neurol. 2009

DL Carden et al.
J. Pathol. 2000

EI Peerschke et al.
Mol. Immunol. 2010

DJ Pinsky et al.
J. Clin. Invest. 1996

HK Eltzschig et al.
N. Engl. J. Med. 2011

GJ del Zoppo et al.
Stroke 1991

MC Hyman et al.
J. Clin. Invest. 2009

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