Epidemiology and molecular pathology of glioma.

Nat Clin Pract Neurol 2006 Sep;2(9):494-503; quiz 1 p following 516

Ohio State University, Columbus, OH 432-10, USA.

Gliomas account for almost 80% of primary malignant brain tumors, and they result in more years of life lost than do any other tumors. Glioblastoma, the most common type of glioma, is associated with very poor survival, so glioma epidemiology has focused on identifying factors that can be modified to prevent this disease. Only two relatively rare factors have so far been conclusively shown to affect glioma risk--exposure to high doses of ionizing radiation, and inherited mutations of highly penetrant genes associated with rare syndromes. In addition, preliminary evidence points to a lower glioma risk among people with allergic conditions and high levels of serum IgE. Recent research has focused on identifying germline polymorphisms associated with risk of glioma, and using molecular markers to classify glial tumors into more-homogenous groups. Because gene products probably interact with environmental factors or developmental signals to produce gliomas, large studies are needed to analyze associations between polymorphisms and glioma. Cohort studies of immune factors and glioma risk are being undertaken to validate the results of case-control studies. Studies of polymorphisms of genetic pathways with strong prior hypotheses are being planned, and whole-genome scans are being proposed to study high-risk families and case-control series. The Brain Tumor Epidemiology Consortium has been formed to co-ordinate these studies.

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References

(Supplied by CrossRef)

P Kleihues et al.
1997

FG Davis et al.
Neuroepidemiology 1997

A Helseth et al.
J Neurosurg 1995

JM Legler et al.
J Natl Cancer Inst 1999

MA Smith et al.
J Natl Cancer Inst 1998

M Wrensch et al.
Neuro-oncol 2002

PD Inskip et al.
Epidemiol Rev 1995

K Ichimura et al.
J Neurooncol 2004

H Ohgaki et al.
Cancer Res 2004

S Preston-Martin et al.
1996

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