Reconstructing Native American population history.

Nature 2012 Aug;488(7411):370-4

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved. One contentious issue is whether the settlement occurred by means of a single migration or multiple streams of migration from Siberia. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call 'First American'. However, speakers of Eskimo-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America.

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http://dx.doi.org/10.1038/nature11258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615710PMC
August 2012
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References

(Supplied by CrossRef)

LL Cavalli-Sforza et al.
1994

DJ Meltzer et al.
2009

T Goebel et al.
Science 2008

TD Dillehay et al.
Proc. Natl Acad. Sci. USA 2009

DH O’Rourke et al.
Curr. Biol. 2010

E Tamm et al.
PLoS ONE 2007

A Kitchen et al.
PLoS ONE 2008

NJ Fagundes et al.
Am. J. Hum. Genet. 2008

JH Greenberg et al.
Curr. Anthropol. 1986

JT Lell et al.
Am. J. Hum. Genet. 2002

MC Bortolini et al.
Am. J. Hum. Genet. 2003

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