Epstein-Barr virus latent genes.

Exp Mol Med 2015 Jan 23;47:e131. Epub 2015 Jan 23.

Department of Medicine, Brigham and Women's Hospital, Program in Virology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA.

Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent with the notion that EBV latent genes are important for malignant cell growth. While the EBV-encoded nuclear antigen-1 (EBNA-1) and latent membrane protein-2A (LMP-2A) are critical, the EBNA-leader proteins, EBNA-2, EBNA-3A, EBNA-3C and LMP-1, are individually essential for in vitro transformation of primary B cells to lymphoblastoid cell lines. EBV-encoded RNAs and EBNA-3Bs are dispensable. In this review, the roles of EBV latent genes are summarized.

Download full-text PDF

Source
http://dx.doi.org/10.1038/emm.2014.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314583PMC
January 2015
4 Reads

Publication Analysis

Top Keywords

latent genes
16
ebv latent
8
epstein-barr virus
8
latent
6
growth ebv-encoded
4
cell growth
4
ebv-encoded nuclear
4
nuclear antigen-1
4
antigen-1 ebna-1
4
lymphoblastoid cell
4
cell lines
4
genes malignant
4
lmp-1 individually
4
limited latent
4
lines ebv-encoded
4
consistent notion
4
ebna-1 latent
4
notion ebv
4
malignant cell
4
membrane protein-2a
4

References

(Supplied by CrossRef)

M Epstein et al.
Lancet 1964

G Henle et al.
J Bacteriol 1966

G Henle et al.
J Infect Dis 1970

G Henle et al.
J Natl Cancer Inst 1969

W Henle et al.
Zentralbl Bakteriol (Orig A) 1972

W Henle et al.
Natl Cancer Inst Monogr 1973

W Henle et al.
Cancer Res 1973

W Henle et al.
Ann Clin Lab Sci 1974

W Henle et al.
Cancer 1974

W Henle et al.
Adv Pathobiol 1976

W Henle et al.
Laryngoscope 1977

Similar Publications