Measuring conformational dynamics of biomolecules by single molecule fluorescence spectroscopy.

Authors:
S Weiss

Nat Struct Biol 2000 Sep;7(9):724-9

Materials Sciences and Physical Biosciences Divisions, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Dynamic structural changes of macromolecules undergoing biochemical reactions can be studied using novel single molecule spectroscopy tools. Recent advances in applying such distance and orientation molecular rulers to biological systems are reviewed, and future prospects and challenges are discussed.

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Source
http://dx.doi.org/10.1038/78941DOI Listing
September 2000

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