Functional diversity of helper T lymphocytes.

Nature 1996 Oct;383(6603):787-93

Immunology Research Division, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.

Download full-text PDF

Source
http://dx.doi.org/10.1038/383787a0DOI Listing
October 1996
1 Read

Publication Analysis

Top Keywords

helper lymphocytes
8
immune responses
8
functions framework
4
framework understanding
4
differentiation lead
4
lead rational
4
rational strategies
4
molecular mechanisms
4
effector functions
4
understanding heterogeneity
4
helper-t-cell differentiation
4
mechanisms helper-t-cell
4
defining cellular
4
cellular molecular
4
responses defining
4
pathological immune
4
secretion patterns
4
normal pathological
4
heterogeneity normal
4
patterns effector
4

References

(Supplied by CrossRef)

JL Turk et al.
Adv. Immunol. 1971

GL Asherson et al.
Immunology 1965

CR Parish et al.
Transplant. Rev. 1972

TR Mosmann et al.
J. Immunol. 1986

DF Fiorentino et al.
J. Exp. Med. 1989

T Sornasse et al.
J. Exp. Med. 1996

TR Mosmann et al.
Annu. Rev. Immunol. 1989

K Bottomly et al.
Immunol. Today 1988

AH Lichtman et al.
Proc. Natl Acad. Sci. USA 1987

FW Fitch et al.
Annu. Rev. Immunol. 1993

A Kelso et al.
Immunol. Today 1995

Similar Publications