Principles of CDK regulation.

Authors:
D O Morgan

Nature 1995 Mar;374(6518):131-4

Department of Physiology, University of California, San Francisco 94143-0444.

As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.

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http://dx.doi.org/10.1038/374131a0DOI Listing
March 1995
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