Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages.

Nature 1992 Nov;360(6401):225-31

Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts.

Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta.

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http://dx.doi.org/10.1038/360225a0DOI Listing
November 1992

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