Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor.

Nature 1992 Sep;359(6390):76-9

Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110.

A critical point during mammalian pregnancy is the implantation of the blastocyst when the embryo attaches to the wall of the uterus. The autonomously developing preimplantation embryo then becomes dependent on the maternal environment for its continued development. Little is known about the regulation of implantation, except that a complex interaction between peptide and steroid hormones synchronizes the preparation of the uterus for implantation with the development of the embryo. Whether the implantation event is under maternal or embryonic control is also unclear (reviewed in refs 1, 2). We have previously shown that a cytokine, leukaemia inhibitory factor (LIF), is expressed in the uterine endometrial glands specifically on the fourth day of pregnancy. This burst of expression is under maternal control and always precedes implantation of the blastocyst. Here we report that transient expression of LIF in mice is essential for implantation. Females lacking a functional LIF gene are fertile, but their blastocysts fail to implant and do not develop. The blastocysts, however, are viable and, when transferred to wild-type pseudopregnant recipients, they can implant and develop to term.

Download full-text PDF

Source
http://dx.doi.org/10.1038/359076a0DOI Listing
September 1992

Publication Analysis

Top Keywords

leukaemia inhibitory
8
inhibitory factor
8
implant develop
8
implantation blastocyst
8
implantation
6
expression maternal
4
expressed uterine
4
lif expressed
4
factor lif
4
burst expression
4
uterine endometrial
4
glands fourth
4
fourth day
4
endometrial glands
4
cytokine leukaemia
4
pregnancy burst
4
day pregnancy
4
control unclear
4
uterus implantation
4
implantation development
4

References

(Supplied by CrossRef)

HM Weitlauf et al.
1988

GD Hodgen et al.
1988

H Bhatt et al.
Proc. natn. Acad. Sci. U.S.A. 1991

DP Gearing et al.
EMBO J. 1987

S Thompson et al.
Cell 1989

M Zjilstra et al.
Nature 1990

AP McMahon et al.
Cell 1990

MR Capecchi et al.
Science 1989

RL Williams et al.
Nature 1988

AG Smith et al.
Nature 1988

V Matsui et al.
Nature 1991

Similar Publications