Genome sequence of Yersinia pestis, the causative agent of plague.

Nature 2001 Oct;413(6855):523-7

The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black Death (fourteenth to nineteenth centuries) and modern plague (nineteenth century to the present day). The recent identification of strains resistant to multiple drugs and the potential use of Y. pestis as an agent of biological warfare mean that plague still poses a threat to human health. Here we report the complete genome sequence of Y. pestis strain CO92, consisting of a 4.65-megabase (Mb) chromosome and three plasmids of 96.2 kilobases (kb), 70.3 kb and 9.6 kb. The genome is unusually rich in insertion sequences and displays anomalies in GC base-composition bias, indicating frequent intragenomic recombination. Many genes seem to have been acquired from other bacteria and viruses (including adhesins, secretion systems and insecticidal toxins). The genome contains around 150 pseudogenes, many of which are remnants of a redundant enteropathogenic lifestyle. The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.

Download full-text PDF

Source
http://www.nature.com/articles/35097083
Publisher Site
http://dx.doi.org/10.1038/35097083DOI Listing
October 2001
1 Read
42.351 Impact Factor

Publication Analysis

Top Keywords

pestis causative
8
yersinia pestis
8
causative agent
8
genome sequence
8
genome
5
plague
5
pestis
5
ongoing genome
4
pestis strain
4
sequence pestis
4
report complete
4
genome fluidity
4
evidence ongoing
4
complete genome
4
co92 consisting
4
three plasmids
4
chromosome three
4
health report
4
consisting 465-megabase
4
465-megabase chromosome
4

References

(Supplied by CrossRef)

RD Perry et al.
Clin. Microbiol. Rev. 1997

M Galimand et al.
N. Engl. J. Med. 1997

M Skurnik et al.
Mol. Microbiol. 2000

M Achtman et al.
Proc. Natl Acad. Sci. USA 1999

JM Doll et al.
Am. J. Trop. Med. Hyg. 1994

JR Lobry et al.
Mol. Biol. Evol. 1996

A Guiyoule et al.
J. Clin. Microbiol. 1997

C Cowan et al.
Infect. Immun. 2000

MB Prentice et al.
J. Bacteriol. 2001

J Hinnebusch et al.
Int. J. Med. Microbiol. 2000

C Buchrieser et al.
Infect Immun. 1999

Similar Publications