Feedback control of intercellular signalling in development.

Authors:
M Freeman

Nature 2000 Nov;408(6810):313-9

MRC Laboratory of Molecular Biology, Cambridge, UK.

The intercellular communication that regulates cell fate during animal development must be precisely controlled to avoid dangerous errors. How is this achieved? Recent work has highlighted the importance of positive and negative feedback loops in the dynamic regulation of developmental signalling. These feedback interactions can impart precision, robustness and versatility to intercellular signals. Feedback failure can cause disease.

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http://dx.doi.org/10.1038/35042500DOI Listing
November 2000

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