A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction.

Nature 1989 Mar;338(6212):229-34

Department of Anatomy, Washington University School of Medicine, St. Louis, Missouri 63110.

A striking example of topographic specificity in synapse formation is the preferential reinnervation of original synaptic sites on denervated muscle fibres by regenerating motor axons. This specificity is mediated by the basal lamina of the synaptic cleft. A glycoprotein, s-laminin, has now been identified that is selectively associated with synaptic basal lamina and is recognized by motoneurons. Molecular cloning reveals that s-laminin is a novel homologue of laminin, a potent promoter of neurite outgrowth.

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http://dx.doi.org/10.1038/338229a0DOI Listing
March 1989

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References

(Supplied by CrossRef)

F Tello et al.
Trab. Lab. Invest. biol. Univ. Madr. 1907

MR Bennett et al.
Cold Spring Harb. Symp. quant. Biol. 1975

JR Sanes et al.
J. Cell Biol. 1978

M Glicksman et al.
J. Neurocytol. 1983

JR Sanes et al.
J. Cell Biol. 1979

JR Sanes et al.
Cold Spring Harbor Symp. quant. Biol. 1983

MJ Anderson et al.
J. Cell Biol. 1983

JR Fallon et al.
Nature 1985

JR Sanes et al.
A. Rev. Neurosci. 1989

DD Hunter et al.
Soc. Neurosci. Abstr. 1987

CF Eldridge et al.
J. Neurocytol. 1986

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