Superhydrophobic surfaces as smart platforms for the analysis of diluted biological solutions.

ACS Appl Mater Interfaces 2012 Jun 4;4(6):3213-24. Epub 2012 Jun 4.

BioNEM Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro , Catanzaro, 88100 Italy.

The aim of this paper is to expound on the rational design, fabrication and development of superhydrophobic surfaces (SHSs) for the manipulation and analysis of diluted biological solutions. SHSs typically feature a periodic array or pattern of micropillars; here, those pillars were modified to incorporate on the head, at the smallest scales, silver nanoparticles aggregates. These metal nanoclusters guarantee superior optical properties and especially SERS (surface enhanced Raman scattering) effects, whereby a molecule, adsorbed on the surface, would reveal an increased spectroscopy signal. On account of their two scale-hybrid nature, these systems are capable of multiple functions which are (i) to concentrate a solution, (ii) to vehicle the analytes of interest to the active areas of the substrate and, therefore, (iii) to measure the analytes with exceptional sensitivity and very low detection limits. Forasmuch, combining different technologies, these devices would augment the performance of conventional SERS substrates and would offer the possibility of revealing a single molecule. In this work, similar SHSs were used to detect Rhodamine molecules in the fairly low atto molar range. The major application of this novel family of devices would be the early detection of tumors or other important pathologies, with incredible advances in medicine.

Download full-text PDF

Source
http://dx.doi.org/10.1021/am300556wDOI Listing
June 2012
6 Reads

Publication Analysis

Top Keywords

analysis diluted
8
biological solutions
8
diluted biological
8
superhydrophobic surfaces
8
interest active
4
active areas
4
analytes interest
4
solution vehicle
4
multiple functions
4
functions concentrate
4
concentrate solution
4
vehicle analytes
4
substrate iii
4
sensitivity low
4
low detection
4
detection limits
4
exceptional sensitivity
4
analytes exceptional
4
capable multiple
4
iii measure
4

Altmetric Statistics

Similar Publications