The HIN-200 family: more than interferon-inducible genes?

Exp Cell Res 2005 Aug;308(1):1-17

Cancer Immunology Division, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, 8006, Victoria, Australia.

The HIN-200 family was initially grouped together based on their hemopoietic expression, interferon-inducibility, nuclear localization, and characteristic 200 amino-acid domains. In this review, we performed a comprehensive search of genome databases and determined the location of previously characterized and predicted genes within the human, mouse, and rat HIN-200 loci. Several novel proteins were predicted in the mouse and rat. We also discuss recent advances in our understanding of this family of proteins and highlight the most important findings. In addition to a role in interferon biology, there is now good evidence supporting a role for these proteins as regulators of cell proliferation and differentiation. The activity of HIN-200 proteins is not restricted to the hemopoietic system as they are expressed and can function in a variety of other cells and tissues. The importance of HIN-200 proteins in disease now is beginning to be understood as they appear to be involved in autoimmunity and may act as tumor suppressor proteins.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2005.03.032DOI Listing
August 2005
42 Reads

Publication Analysis

Top Keywords

mouse rat
8
hin-200 proteins
8
hin-200 family
8
proteins
6
hin-200
5
expressed function
4
characterized predicted
4
predicted genes
4
addition role
4
genes human
4
role interferon
4
human mouse
4
location characterized
4
genome databases
4
variety cells
4
search genome
4
interferon biology
4
databases determined
4
determined location
4
function variety
4

Similar Publications