Complement and its role in protection and pathogenesis of flavivirus infections.

Vaccine 2008 Dec;26 Suppl 8:I100-7

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, United States.

The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review, we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768071PMC
http://dx.doi.org/10.1016/j.vaccine.2008.11.061DOI Listing
December 2008
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