WNT Signaling in Cancer Immunosurveillance.

Trends Cell Biol 2019 01 13;29(1):44-65. Epub 2018 Sep 13.

Departamento de Biología Funcional, Área de Inmunología, Universidad de Oviedo. Instituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (IISPA), 33011 Oviedo, Asturias, Spain. Electronic address:

Deregulated WNT signaling has been shown to favor malignant transformation, tumor progression, and resistance to conventional cancer therapy in a variety of preclinical and clinical settings. Accumulating evidence suggests that aberrant WNT signaling may also subvert cancer immunosurveillance, hence promoting immunoevasion and resistance to multiple immunotherapeutics, including immune checkpoint blockers. Here, we discuss the molecular and cellular mechanisms through which WNT signaling influences cancer immunosurveillance and present potential therapeutic avenues to harness currently available WNT modulators for cancer immunotherapy.

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http://dx.doi.org/10.1016/j.tcb.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001864PMC
January 2019
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