Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention.

Mol Aspects Med 2016 08 19;50:56-87. Epub 2016 Apr 19.

Université de Montpellier, INRA, UMR 866 Dynamique Musculaire et Métabolisme, Montpellier F-34060, France.

Identification of cost-effective interventions to maintain muscle mass, muscle strength, and physical performance during muscle wasting and aging is an important public health challenge. It requires understanding of the cellular and molecular mechanisms involved. Muscle-deconditioning processes have been deciphered by means of several experimental models, bringing together the opportunities to devise comprehensive analysis of muscle wasting. Studies have increasingly recognized the importance of fatty infiltrations or intermuscular adipose tissue for the age-mediated loss of skeletal-muscle function and emphasized that this new important factor is closely linked to inactivity. The present review aims to address three main points. We first mainly focus on available experimental models involving cell, animal, or human experiments on muscle wasting. We next point out the role of intermuscular adipose tissue in muscle wasting and aging and try to highlight new findings concerning aging and muscle-resident mesenchymal stem cells called fibro/adipogenic progenitors by linking some cellular players implicated in both FAP fate modulation and advancing age. In the last part, we review the main data on the efficiency and molecular and cellular mechanisms by which exercise, replacement hormone therapies, and β-hydroxy-β-methylbutyrate prevent muscle wasting and sarcopenia. Finally, we will discuss a potential therapeutic target of sarcopenia: glucose 6-phosphate dehydrogenase.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mam.2016.04.006DOI Listing
August 2016
8 Reads

Publication Analysis

Top Keywords

muscle wasting
24
experimental models
12
wasting aging
12
muscle
8
intermuscular adipose
8
fatty infiltrations
8
adipose tissue
8
wasting
5
wasting point
4
point role
4
mesenchymal stem
4
experiments muscle
4
human experiments
4
cell animal
4
animal human
4
role intermuscular
4
tissue muscle
4
findings concerning
4
concerning aging
4
involving cell
4

Similar Publications