Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability.

DNA Repair (Amst) 2014 Jul 21;19:143-51. Epub 2014 Apr 21.

Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd. R1800, Austin, TX 78723, United States. Electronic address:

Repetitive genomic sequences can adopt a number of alternative DNA structures that differ from the canonical B-form duplex (i.e. non-B DNA). These non-B DNA-forming sequences have been shown to have many important biological functions related to DNA metabolic processes; for example, they may have regulatory roles in DNA transcription and replication. In addition to these regulatory functions, non-B DNA can stimulate genetic instability in the presence or absence of DNA damage, via replication-dependent and/or replication-independent pathways. This review focuses on the interactions of non-B DNA conformations with DNA repair proteins and how these interactions impact genetic instability.

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http://dx.doi.org/10.1016/j.dnarep.2014.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216180PMC
July 2014
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