Pertussis vaccines and the challenge of inducing durable immunity.

Curr Opin Immunol 2015 Aug 17;35:48-54. Epub 2015 Jun 17.

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Vanderbilt Vaccine Research Program, Vanderbilt University, 21st Avenue South, S 2323 MCN, Nashville, TN 37232, USA. Electronic address:

Pertussis has re-emerged as an important public health concern. In the 1990s whole-cell pertussis vaccines were replaced with less reactogenic acellular vaccines consisting of purified pertussis components. However, recent data show that protection from acellular pertussis vaccines is not long-lasting. Antibody levels wane rapidly following vaccination, likely a result of the inability of acellular pertussis antigens to stimulate long-lasting B cell memory. In addition, T cell responses to acellular pertussis vaccines are mixed Th2/Th1, while whole-cell pertussis vaccination and infection stimulate Th17 responses, important for host defense against extracellular mucosal pathogens. Consistent with this T cell skewing, acellular vaccines did not prevent colonization or transmission following challenge in nonhuman primates while whole-cell vaccinated and previously infected animals cleared the infection more rapidly.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S09527915150008
Publisher Site
http://dx.doi.org/10.1016/j.coi.2015.05.008DOI Listing
August 2015
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