Non-alcoholic steatohepatitis and cancer.

Authors:
E Bugianesi

Clin Liver Dis 2007 Feb;11(1):191-207, x-xi

Division of Gastro-Hepatology, Department of Internal Medicine, San Giovanni Battista Hospital, University of Turin, Turin, Italy.

Hepatocellular carcinoma (HCC) is part of the natural history of non-alcoholic steatohepatitis (NASH). A significant proportion of people who have cryptogenic cirrhosis develop HCC. NASH-related cirrhosis carries a substantial risk for early HCC development. Diagnosis of HCC often is made at first referral; the tumor usually is large with multiple localizations. Patients who have obesity or diabetes are at risk for HCC and a variety of cancers. Given the epidemic of obesity and diabetes, the incidence of NASH-related HCC is expected to increase. In addition to developing new diagnostic tools and pharmacologic therapies, efforts should be directed at preventing non-alcoholic fatty liver disease.

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Source
http://dx.doi.org/10.1016/j.cld.2007.02.006DOI Listing
February 2007
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