Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.

Cell Rep 2015 Oct 1;13(2):267-76. Epub 2015 Oct 1.

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel. Electronic address:

Genomic mutations in key genes are known to drive tumorigenesis and have been the focus of much attention in recent years. However, genetic content also may change farther downstream. RNA editing alters the mRNA sequence from its genomic blueprint in a dynamic and flexible way. A few isolated cases of editing alterations in cancer have been reported previously. Here, we provide a transcriptome-wide characterization of RNA editing across hundreds of cancer samples from multiple cancer tissues, and we show that A-to-I editing and the enzymes mediating this modification are significantly altered, usually elevated, in most cancer types. Increased editing activity is found to be associated with patient survival. As is the case with somatic mutations in DNA, most of these newly introduced RNA mutations are likely passengers, but a few may serve as drivers that may be novel candidates for therapeutic and diagnostic purposes.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.08.080DOI Listing
October 2015
7 Reads

Publication Analysis

Top Keywords

rna editing
12
editing activity
8
editing
6
multiple cancer
4
samples multiple
4
cancer samples
4
hundreds cancer
4
editing hundreds
4
cancer tissues
4
a-to-i editing
4
mediating modification
4
enzymes mediating
4
editing enzymes
4
characterization rna
4
tissues a-to-i
4
provide transcriptome-wide
4
isolated cases
4
flexible isolated
4
dynamic flexible
4
blueprint dynamic
4

Similar Publications