Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Cell 2017 Jun;169(6):985-999

Hubrecht Institute, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S00928674173054
Publisher Site
http://dx.doi.org/10.1016/j.cell.2017.05.016DOI Listing
June 2017
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