Wnt signaling: multivesicular bodies hold GSK3 captive.

Cell 2010 Dec;143(7):1044-6

German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Division of Molecular Embryology, Im Neuenheimer Feld 581, Heidelberg, Germany.

Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a new framework for understanding Wnt signaling.

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http://dx.doi.org/10.1016/j.cell.2010.12.003DOI Listing
December 2010
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