Curr Opin Cell Biol 2004 Oct;16(5):513-21
Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Osaka 565-0871, Japan.
Immunoglobulin-like nectins contribute to the formation of a variety of cell-cell junctions, acting cooperatively with, or independently of, cadherins. In addition, nectins heterophilically trans-interact with nectin-like molecules (Necls), which are involved in cell adhesion, migration, and proliferation, and assist or modify their functions. On the other hand, nectins and Necls serve as viral receptors and are associated with human diseases (including cancer) when mutated or upregulated.