Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population.

Biochem Biophys Res Commun 2005 Apr;329(4):1234-9

Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Japan.

We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p=0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p=0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.

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http://dx.doi.org/10.1016/j.bbrc.2005.02.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092916PMC
April 2005
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