Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams.

Am J Obstet Gynecol 2012 Jun 6;206(6):507.e1-10. Epub 2012 Apr 6.

Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX 77555-1062, USA.

Objective: Examine temporal alterations in vascular angiotensin II receptors (AT(1)R and AT(2)R) and determine vascular response to angiotensin II in growth-restricted offspring.

Study Design: Offspring of pregnant rats fed low-protein (6%) and control (20%) diet were compared.

Results: Prenatal protein restriction reprogrammed AT(1a)R messenger RNA expression in male rats' mesenteric arteries to cause 1.7- and 2.3-fold increases at 3 and 6 months of age associated with arterial pressure increases of 10 and 33 mm Hg, respectively; however, in female rats, increased AT(1a)R expression (2-fold) and arterial pressure (15 mm Hg) occurred only at 6 months. Prenatal protein restriction did not affect AT(2)R expression. Losartan abolished hypertension, suggesting that AT(1a)R plays a primary role in arterial pressure elevation. Vasoconstriction to angiotensin II was exaggerated in all protein-restricted offspring, with greater potency and efficacy in male rats.

Conclusion: Prenatal protein restriction increased vascular AT(1)R expression and vasoconstriction to angiotensin II, possibly contributing to programmed hypertension.

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Source
http://dx.doi.org/10.1016/j.ajog.2012.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361632PMC
June 2012
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