Serum vascular endothelial growth factor-a levels during induction therapy in children with acute lymphoblastic leukemia.

Indian Pediatr 2013 Jul 5;50(7):659-62. Epub 2012 Dec 5.

Pediatric Hematology Oncology and BMT, Department of Pediatrics, Institute of Child Health, India.

Objective: To evaluate serum vascular endothelial growth factor (VEGF) levels in children with acute lymphoblastic leukemia (ALL) during the induction phase of chemotherapy.

Design: Prospective sudy.

Setting: Setting: Hospital-based study over 18 months.

Patients: 30 children with ALL and 17 healthy age- and sex-matched controls.

Intervention: Serum concentration of VEGF-A-165 isoform (s-VEGF) was measured by enzyme-linked immunoabsorbant assay at diagnosis and at the end of induction chemotherapy.

Main Outcome Measures: s-VEGF was compared with markers of tumor burden. Kinetics of s-VEGF was assessed in response to induction chemotherapy.

Results: Median VEGF was significantly lower in untreated patients than in controls (17.0 vs. 42.6 pg/mL, P=0.004). s-VEGF levels were fairly correlated with WBC count (r=-0.56, P=0.004) and LDH (r=-0.52, P=0.02) at diagnosis. All patients but one were in morphologic remission at the end of induction. Median s-VEGF concentration on day 29/33 was significantly higher than on day 1 (44.2 pg/mL, P=0.009).

Conclusions: Untreated children with ALL have significantly lower s-VEGF concentration than controls. At the end of the induction therapy, s-VEGF increased to levels similar to controls. The role of ligand-receptor interaction between VEGF and VEGF receptors on leukemia cells needs to be further delineated.To identify the risk factors for scholastic backwardness in children.

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http://dx.doi.org/10.1007/s13312-013-0198-6DOI Listing
July 2013
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References

(Supplied by CrossRef)

R Koomagi et al.
Clin Cancer Res 2001

K Podar et al.
Blood 2005

J Homsi et al.
Cancer Control 2007

S Yetgin et al.
Leuk Lymphoma 2001

S Aref et al.
Hematology 2007

Q Hu et al.
Cancer 2004

M Albitar et al.
Cancer 2004

FJ Giles et al.
Leuk Res 2004

WT Bellamy et al.
Cancer Res 1999

S Baruchel et al.
J Clin Oncol 2011

HQ Yang et al.
Zhongguo Dang Dai Er Ke Za Zhi 2007

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