A Review of Onychomycosis Due to Aspergillus Species.

Mycopathologia 2018 Jun 16;183(3):485-493. Epub 2017 Nov 16.

The National Aspergillosis Centre, Education and Research Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester, M23 9LT, UK.

Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. have recently been described to cause nail infections. The following criteria are required to diagnose onychomycosis due to Aspergillus spp.: (1) positive direct microscopy and (2) repeated culture or molecular detection of Aspergillus spp., provided no dermatophyte was isolated. A review of 42 epidemiological studies showed that onychomycosis due to Aspergillus spp. varies between < 1 and 35% of all cases of onychomycosis in the general population and higher among diabetic populations accounting for up to 71% and the elderly; it is very uncommon among children and adolescence. Aspergillus spp. constitutes 7.7-100% of the proportion of NDMO. The toenails are involved 25 times more frequently than fingernails. A. flavus, A. terreus and A. niger are the most common aetiologic species; other rare and emerging species described include A. tubingensis, A. sydowii, A. alliaceus, A. candidus, A. versicolor, A. unguis, A. persii, A. sclerotiorum, A. uvarum, A. melleus, A. tamarii and A. nomius. The clinical presentation of onychomycosis due to Aspergillus spp. is non-specific but commonly distal-lateral pattern of onychomycosis. A negative culture with a positive KOH may point to a NDM including Aspergillus spp., as the causative agent of onychomycosis. Treatment consists of systemic therapy with terbinafine or itraconazole.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11046-017-0222-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958150PMC
June 2018
7 Reads
1 Citation
1.530 Impact Factor

Publication Analysis

Top Keywords

aspergillus spp
20
onychomycosis aspergillus
12
aspergillus
6
spp
5
nail infections
4
infections criteria
4
criteria required
4
provided dermatophyte
4
described nail
4
isolated review
4
spp described
4
dermatophyte isolated
4
required diagnose
4
spp positive
4
molecular detection
4
microscopy repeated
4
repeated culture
4
direct microscopy
4
detection aspergillus
4
spp provided
4

References

(Supplied by CrossRef)

G Moreno et al.
Clin Dermatol 2010

AK Gupta et al.
J Am Acad Dermatol 2012

MP English et al.
Br J Dermatol 1974

M Motamedi et al.
Jundishapur J Microbiol 2016

M Richardson et al.
Dermatology 1997

EO Martínez-Herrera et al.
An Bras Dermatol 2015

F Zarei et al.
Mycoses 2015

M Zotti et al.
Exp Dermatol 2015

P Bowyer et al.
Curr Infect Dis Rep 2011

BM Piraccini et al.
J Am Acad Dermatol 2010

Similar Publications