Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children.

Eur J Pediatr 2010 Sep 8;169(9):1119-22. Epub 2010 Apr 8.

Department of Pediatrics, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only approximately 50% of infected children, the actual infection rate in our cohort is estimated to approximately 10%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine should be undertaken.

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http://dx.doi.org/10.1007/s00431-010-1192-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908438PMC
September 2010
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