Quantitative assessment of emphysema, air trapping, and airway thickening on computed tomography.

Lung 2008 May-Jun;186(3):157-165. Epub 2008 Mar 20.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Research Institute of Radiology, 388-1, Pungnap-dong, Songpa-ku, Seoul, 138-736, Korea.

The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by airflow limitation but also by factors such as exercise capacity and body mass index. Recent advances in CT technology suggest that it might be a useful tool for evaluating the severity of the disease components of COPD. The aim of this study is to evaluate the correlation between the parameters measured on volumetric CT, including the extent of emphysema, air trapping, and airway thickening, and clinical parameters. CT scans were performed in 34 patients with COPD at full inspiration and expiration. We used in-house software to measure CT parameters, including volume fraction of emphysema (V(950)), mean lung density (MLD), CT air trapping index (CT ATI), segmental bronchial wall area (WA), lumen area (LA), and wall area percent (WA%). We found that the CT parameters were correlated with the pulmonary function test (PFT) results, body mass index (BMI), the modified Medical Research Council Dyspnea scale (MMRC scale), the six-minute-walk distance (6MWD), and the BODE index. V(950 insp) correlated to the BMI, FEV(1), 6MWD, and the BODE index. The CT ATI correlated with the physiologic ATI (VC-FVC) (R=0.345, p=0.045) and the MMRC scale (R=0.532, p=0.001). There was a positive correlation between the WA% and the BMI (R=0.563, p<0.001). MLD(exp) showed the strongest correlation with the BODE index (R= -0.756, p<0.001). We conclude that the severity of emphysema and air trapping measured on CT correlated with the PFT parameters 6MWD and BMI.

Download full-text PDF

Source
http://www.springerlink.com/index/w31473126q7v1313.pdf
Web Search
http://link.springer.com/content/pdf/10.1007/s00408-008-9071
Web Search
http://dx.doi.org/10.1007/s00408-008-9071-0DOI Listing
November 2008
4 Reads

Publication Analysis

Top Keywords

air trapping
12
emphysema air
8
wall area
8
trapping airway
8
6mwd bode
8
mmrc scale
8
body mass
8
airway thickening
8
bronchial wall
4
ati segmental
4
mld air
4
trapping ati
4
segmental bronchial
4
area wall
4
wa% parameters
4
parameters correlated
4
correlated pulmonary
4
percent wa%
4
area percent
4
lumen area
4

Altmetric Statistics

References

(Supplied by CrossRef)

American Thoracic Society et al.
Am J Respir Crit Care Med 1995

C Bergin et al.
Am Rev Respir Dis 1986

NL Müller et al.
Chest 1988

PA Gevenois et al.
Am J Respir Crit Care Med 1995

PA Gevenois et al.
Am J Respir Crit Care Med 1996

PA Gevenois et al.
Radiology 1996

M Kinsella et al.
Chest 1990

K Nishimura et al.
J Thorac Imaging 1998

Y Nakano et al.
Thorax 1999

Y Nakano et al.
Am J Respir Crit Care Med 2000

M Mishima et al.
J Comput Assist Tomogr 1999

Similar Publications