The effect of interleukin-1 blockade on fatigue in rheumatoid arthritis--a pilot study.

Rheumatol Int 2005 Aug 8;25(6):481-4. Epub 2004 Apr 8.

Clinical Immunology Unit, Department of Medicine, Rogaland Central Hospital, 4068, Stavanger, Norway.

Fatigue occurs in many patients with rheumatoid arthritis (RA) and other chronic inflammatory diseases and may be defined as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion. It can be restrictive and severely disabling. We recently found more than 3/4 of systemic lupus erythematosus patients to be significantly affected by this phenomenon. We hypothesized that fatigue in patients with RA might be comparable to sickness behavior in animals possibly caused by disturbances in interleukin-1 beta signaling pathways and thus accessible to blockade by biologic agents. This study compared measures of disease behavior and fatigue symptoms in eight RA patients before and at three time points during treatment with daily administration of anakinra.

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http://link.springer.com/10.1007/s00296-004-0463-z
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http://dx.doi.org/10.1007/s00296-004-0463-zDOI Listing
August 2005

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References

(Supplied by CrossRef)

Wolfe et al.
J Rheumatol 1996

Koike et al.
Mod Rheumatol 2000

Krupp et al.
J Rheumatol 1990

Tench et al.
Rheumatology 2000

Omdal et al.
J Rheumatol 2002

Comi et al.
J Neurol 2001

Krupp et al.
Curr Opin Neurol 1996

Kelley et al.
Ann N Y Acad Sci 1997

Rinehart et al.
Cancer Invest 1997

Farrar et al.
Endocrinology 1987

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