Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG).

Psychopharmacology (Berl) 1989 ;98(3):297-303

Pro Science Private Research Institute GmbH, Linden, Federal Republic of Germany.

Telemetric recordings of field potentials from frontal cortex, hippocampus, striatum and reticular formation of freely moving rats were analysed before and after injection of the enantiomeric hallucinogenic amphetamine derivatives R-DOB [(-)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane], R-DOM [(-)-1-(2,5-dimethoxy-4-methylphenyl)-2-amino-propane] and R-DOI [(-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane] as well as the nonhallucinogenic amphetamine derivatives S-MBDB [(+)-N-methyl-1-(1,3-benzodioxol-5-yl)butanamine] and S-MDMA [(+)-3,4-methylenedioxymethamphetamine] and S-(+)-amphetamine. The frequency analysis of the field potentials revealed a clearcut difference between them. The spectral patterns emerging after injection of the non-hallucinogens were characterized by a general decrease of power, the changes in the alpha2 and delta band being the most prominent, whereas only after the application of the hallucinogenic compounds was a contrasting increase of power observed in the alpha 1 frequency band, especially in the striatum. As increases in alpha 1 power have been correlated in the same pharmacological model to serotonergic control mechanisms, the results are in line with the hypothesis that 5-HT2 receptors, predominantly occurring in the striatum, might be involved in the hallucinogenic action of drugs.

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http://dx.doi.org/10.1007/bf00451678DOI Listing
August 1989

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References

(Supplied by CrossRef)

H Ahrens et al.
1974

W Dimpfel et al.
Neuropsychobiology 1986

W Dimpfel et al.
Neuropsychobiology 1986

W Dimpfel et al.
Neuropsychobiology 1987

W Dimpfel et al.
Neuropsychobiology 1988

RA Glennon et al.
Psychopharmacol Bull 1986

MP Johnson et al.
Eur J Pharmacol 1986

RA Lyon et al.
Eur J Pharmacol 1988

R Oberlender et al.
Psychopharmacology 1988

A Pazos et al.
Brain Res 1985

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