The novel sarcomeric protein telethonin exhibits developmental and functional regulation.

Biochem Biophys Res Commun 1999 Apr;257(3):699-703

Molecular Physiology Unit, Department of Veterinary Basic Sciences, The Royal Veterinary College, NWI 0TU, London,

We have isolated a cDNA clone from a mouse skeletal muscle library which is preferentially expressed in striated muscle and exhibits a high homology to human telethonin, a sarcomeric protein. The mouse telethonin transcript is developmentally regulated in both cardiac and skeletal muscle in vivo and is down-regulated in response to denervation. In the C2C12 muscle cell-line the mouse telethonin transcript exhibited a pattern of accumulation similar to that observed for a contractile protein and suggests a role in myofibrillar assembly.

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http://dx.doi.org/10.1006/bbrc.1999.0531DOI Listing
April 1999

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