Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection.

Rev Med Virol 2007 Jul-Aug;17(4):253-76

National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

We reviewed studies that reported results of systematic cytomegalovirus (CMV) screening on fetuses and/or live-born infants. The overall birth prevalence of congenital CMV infection was 0.64%, but varied considerably among different study populations. About 11% of live-born infants with congenital CMV infection were symptomatic, but the inter-study differences in definitions of symptomatic cases limit the interpretation of these data. Non-white race, low socioeconomic status (SES), premature birth, and neonatal intensive care unit admittance were risk factors for congenital CMV infection. Birth prevalence increased with maternal CMV seroprevalence. Maternal seroprevalence accounted for 29% of the variance in birth prevalence between study populations. Maternal seroprevalence and birth prevalence were both higher in study populations that were ascertained at birth rather than in the prenatal period. Thus, timing of ascertainment should be considered when interpreting birth prevalence estimates. Birth prevalence was inversely correlated with mean maternal age, but this relationship was not significant when controlling for maternal seroprevalence. The rate of transmission to infants born to mothers who had a primary infection or a recurrent infection during pregnancy was 32% and 1.4%, respectively. Possible maternal primary infections (i.e. seropositive mother with CMV IgM) resulted in congenital infections about 20% of the time, but are likely to represent a mixture of primary and recurrent infections. In summary, CMV is a common congenital infection worldwide that can lead to permanent disabilities. There is an urgent need for interventions that can reduce the substantial burden of this often overlooked disease.

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http://dx.doi.org/10.1002/rmv.535DOI Listing
August 2007
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References

(Supplied by CrossRef)

Mocarski et al.
2001

Pass et al.
2001

Institute of Medicine (US) Committee to Study Priorities for Vaccine Development et al.
2000

Arvin et al.
Clin Infect Dis 2004

Cannon et al.
BMC Public Health 2005

Nigro et al.
N Engl J Med 2005

Maine et al.
Expert Rev Mol Diagn 2001

Fowler et al.
J Pediatr 1999

Kimberlin et al.
J Pediatr 2003

el Nawawy et al.
J Trop Pediatr 1996

Gaytant et al.
J Med Virol 2005

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