Protein-resistant surfaces prepared by PEO-containing block copolymer surfactants.

J Biomed Mater Res 1989 Mar;23(3):351-68

Department of Materials Science and Engineering, University of Utah, Salt Lake City 84112.

Polyethylene oxide(PEO)-containing nonionic polymeric surfactants were studied as a possible means to produce PEO-rich surfaces by a simple coating treatment of a common hydrophobic medical material--polyethylene. Surface tension and adsorption properties of PEO/polypropylene oxide(PPO) and PEO/polybutylene oxide(PBO) block copolymer surfactants on a hydrophobic surface (low density polyethylene, LDPE) were investigated, using the Wilhelmy plate surface tension technique and x-ray photoelectron spectroscopy(XPS). The protein resistance of the surfactant-treated surfaces was evaluated by XPS and 125I-labeled proteins. The data presented indicate that adsorption of the surfactants on LDPE is dependent on the molecular geometry of the surfactants. Adsorption of human albumin was significantly decreased on the surfactant-treated LDPE surfaces, as compared with the untreated surface. Surfactants suitable for the preparation of PEO-rich surfaces and possible mechanisms for their protein resistance are discussed.

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http://dx.doi.org/10.1002/jbm.820230306DOI Listing
March 1989
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References

(Supplied by CrossRef)

Vroman et al.
1967

Andrade et al.
Med. Instrum. 1973

Coleman et al.
J. Biomed. Mater. Res. 1982

Coleman et al.
1980

Merrill et al.
ASAIO J. 1983

Bailey et al.
1976

Kjellander et al.
J. Chem. Soc., Faraday Trans., 1. 1981

Nagaoka et al.
1984

Bongrand et al.
1984

Osmond et al.
Colloid Polymer Sci. 1983

Napper et al.
J. Colloid Interface Sci. 1977

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