The global health burden of infection-associated cancers in the year 2002.

Int J Cancer 2006 Jun;118(12):3030-44

Clinical Trials Service Unit and Epidemiological Studies Unit, University of Oxford, Headington, UK.

Several infectious agents are considered to be causes of cancer in humans. The fraction of the different types of cancer, and of all cancers worldwide and in different regions, has been estimated using several methods; primarily by reviewing the evidence for the strength of the association (relative risk) and the prevalence of infection in different world areas. The estimated total of infection-attributable cancer in the year 2002 is 1.9 million cases, or 17.8% of the global cancer burden. The principal agents are the bacterium Helicobacter pylori (5.5% of all cancer), the human papilloma viruses (5.2%), the hepatitis B and C viruses (4.9%), Epstein-Barr virus (1%), human immunodeficiency virus (HIV) together with the human herpes virus 8 (0.9%). Relatively less important causes of cancer are the schistosomes (0.1%), human T-cell lymphotropic virus type I (0.03%) and the liver flukes (0.02%). There would be 26.3% fewer cancers in developing countries (1.5 million cases per year) and 7.7% in developed countries (390,000 cases) if these infectious diseases were prevented. The attributable fraction at the specific sites varies from 100% of cervix cancers attributable to the papilloma viruses to a tiny proportion (0.4%) of liver cancers (worldwide) caused by liver flukes.

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.21731DOI Listing
June 2006
5 Reads

Publication Analysis

Top Keywords

year 2002
8
liver flukes
8
cancers worldwide
8
papilloma viruses
8
cancer
6
cancers
5
cancer schistosomes
4
schistosomes 01%
4
09% cancer
4
herpes virus
4
human herpes
4
bacterium helicobacter
4
virus 09%
4
human t-cell
4
type 003%
4
003% liver
4
virus type
4
lymphotropic virus
4
hiv human
4
t-cell lymphotropic
4

References

(Supplied by CrossRef)

Parkin et al.
1999

Ferlay et al.
2004

Mueller et al.
2005

Parkin et al.
2002

J Natl Cancer Inst 2000

Ries et al.
2004

Sriplung et al.
Cancer 2004

Cole et al.
Brit J Prev Soc Med 1971

Walboomers et al.
J Pathol 1999

1994

Similar Publications