Ubiquitin in the immune system.

EMBO Rep 2014 Jan 27;15(1):28-45. Epub 2013 Dec 27.

Centre for Cell Death, Cancer, and Inflammation (CCCI) UCL Cancer Institute, University College London, London, UK.

Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of the different cell types that constitute the immune system. Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self-tolerance.

Download full-text PDF

Source
http://dx.doi.org/10.1002/embr.201338025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303447PMC
January 2014
4 Reads

Publication Analysis

Top Keywords

immune system
12
proper functioning
4
ensuring proper
4
functioning cell
4
cell types
4
types constitute
4
response ensuring
4
constitute immune
4
orchestration immune
4
play crucial
4
deubiquitination play
4
crucial roles
4
roles development
4
system provide
4
development immune
4
immune response
4
provide overview
4
system host
4
ubiquitin system
4
host defence
4

References

(Supplied by CrossRef)
‘Covalent affinity’ purification of ubiquitin-activating enzyme
Ciechanover et al.
J Biol Chem 1982
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown
Hershko et al.
J Biol Chem 1983
Building ubiquitin chains: E2 enzymes at work
Ye et al.
Nat Rev Mol Cell Biol 2009
RING domain E3 ubiquitin ligases
Deshaies et al.
Annu Rev Biochem 2009

Similar Publications