The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis.

Eur J Immunol 1981 Mar;11(3):195-9

The isolation and propagation of functional antigen-specific lines of T lymphoblasts is described. These lines were found to recognize foreign or self antigens in association with accessory cells of syngeneic major histocompatibility complex genotype. Intravenous inoculation of a T cell reactive only against myelin basic protein led to development of clinical paralysis in syngeneic rats. Thus, it is possible to study biological function as well as antigen specificity using T cell lines.

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http://doi.wiley.com/10.1002/eji.1830110307
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http://dx.doi.org/10.1002/eji.1830110307DOI Listing
March 1981

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