Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol.

Brain Behav 2017 02 14;7(2):e00615. Epub 2017 Jan 14.

Department of Psychiatry University of Texas Health Science Center at San Antonio San Antonio TX USA.

Background: In preparation for longitudinal analyses of white matter development in youths with family histories of substance use disorders (FH+) or without such histories (FH-), we examined the reproducibility and reliability of global and regional measures of fractional anisotropy (FA) values, measured using the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA)-diffusion tensor imaging (DTI) protocol. Highly reliable measures are necessary to detect any subtle differences in brain development.

Methods: First, we analyzed reproducibility data in a sample of 12 healthy young adults (ages 20-28) imaged three times within a week. Next, we calculated the same metrics in data collected 1-year apart in the sample of 68 FH+ and 21 FH- adolescents. This is a timeframe where within subject changes in white matter microstructure are small compared to between subject variance. Reproducibility was estimated by examining mean coefficients of variation (MCV), mean absolute differences (MAD), and intraclass correlations (ICC) for global and tract-specific FA values.

Results: We found excellent reproducibility for whole-brain DTI-FA values and most of the white matter tracts, except for the corticospinal tract and the fornix in both adults and youths. There was no significant effect of FH-group on reproducibility (=.4). Reproducibility metrics were not significantly different between adolescents and adults (all > .2). In post hoc analyses, the reproducibility metrics for regional FA values showed a strong positive correlation (= .6) with the regional FA heritability measures previously reported by ENIGMA-DTI.

Conclusion: Overall, this study demonstrated an excellent reproducibility of ENIGMA-DTI FA, positing it as viable analysis tools for longitudinal studies and other protocols that repeatedly assess white matter microstructure.

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http://dx.doi.org/10.1002/brb3.615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318368PMC
February 2017
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References

(Supplied by CrossRef)
Lifespan trajectory of myelin integrity and maximum motor speed
Bartzokis et al.
Neurobiology of Aging 2010
MR diffusion tensor spectroscopy and imaging
Basser et al.
Biophysical Journal 1994
Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype
Carballedo et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics. 2012

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