Br J Urol 1998 Dec;82(6):902-5
Department of Urology, St James' University Hospital, Leeds, UK.
BJU Int 1999 Nov;84(7):854-60
Pyrah Department of Urology, St James University Hospital, Leeds, UK.
Objectives: To determine the response of mechanosensitive pelvic nerve afferents, arising from the rat urinary bladder, to the purinergic agonist alpha,beta-methylene ATP and to the purinergic antagonist suramin.
Materials And Methods: Using a newly developed in vitro bladder-pelvic nerve afferent model, multiunit recordings were taken from mechanosensitive pelvic nerve afferents arising from the rat urinary bladder, in response to bladder distension. Control experiments were performed by distending the bladder with saline at 0. Read More
Am J Physiol Renal Physiol 2006 Jun 10;290(6):F1478-87. Epub 2006 Jan 10.
Division of Gastroenterology, Hepatology, and Nutrition, Univ. of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Chronic pelvic pain (CPP) disorders frequently overlap. We have demonstrated that acute and chronic colonic irritation can lead to neurogenic cystitis. We hypothesize that acute colonic irritation can sensitize urinary bladder afferents to mechanical and chemical stimuli. Read More
Neurosci Res 1995 Sep;23(2):195-205
Department of Physiology, University of Leeds, United Kingdom.
(1) Somato-visceral and viscero-visceral reflex interactions have been studied in the bladder branches of the pelvic nerve and in the electromyographic (EMG) activity of the periurethral skeletal muscles of the anesthetized rat, and by observations of changes in bladder motility. (2) Slow distensions of the bladder caused some elevation of intravesical pressure, and culminated in a micturition contraction. Periurethral EMG activity increased gradually during the bladder distension, and showed an oscillatory marked increase during the bladder contraction. Read More
J Urol 2013 Sep 28;190(3):1123-30. Epub 2013 Mar 28.
Department of Urology, Antwerp University Hospital and Faculty of Medicine, University of Antwerp, Antwerp, Belgium.
Purpose: Pelvic organ neural cross-talk is mediated by central and peripheral pathways. We investigated the effects of colorectal distention at the peripheral level on mechanosensitive bladder single unit afferent activity.
Materials And Methods: We used 16 female Sprague-Dawley® rats in this study. Read More