Search our Database of Scientific Publications and Authors

I’m looking for a

    Details and Download Full Text PDF:
    Results of chemotherapy for cats with alimentary malignant lymphoma: 21 cases (1993-1997)

    J Am Vet Med Assoc 1998 Oct;213(8):1144-9
    Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616-8734, USA.
    Objective: To determine clinical and pathologic findings in cats with alimentary malignant lymphoma and results of treatment with a combination of prednisone, L-asparaginase, vincristine, cyclophosphamide, doxorubicin, and methotrexate.

    Design: Retrospective study.

    Animals: 21 cats with alimentary malignant lymphoma.

    Procedure: Medical records were reviewed, and information on signalment, clinical history and signs, previous treatments, and results of laboratory tests, thoracic radiography, and abdominal ultrasonography were obtained.

    Results: Test results in all cats were negative for FeLV; 3 of 19 were positive for feline immunodeficiency virus. Thirteen tumors were stage III, 7 were stage IV, and 1 was stage V. Diagnosis was confirmed on the basis of microscopic examination of histologic (n = 13) or cytologic (8) specimens. Immunophenotyping was performed on 13 tumors; 10 were T-cell and 3 were B-cell lymphomas. Overall median duration of first remission was 20 weeks. Overall median survival time was 40 weeks. The only factor significantly associated with duration of first remission was whether cats had a complete response following induction chemotherapy; duration of first remission was significantly associated with survival time. Cats tolerated treatment well; only 1 cat had a delay in the treatment schedule because of neutropenia.

    Clinical Implications: Use of a multidrug chemotherapeutic protocol that includes L-asparaginase and doxorubicin results in minimal adverse effects and prolonged survival times in cats with alimentary malignant lymphoma.

    Similar Publications

    Therapy for Australian cats with lymphosarcoma.
    Aust Vet J 2001 Dec;79(12):808-17
    Department of Veterinary Clinical Sciences, Faculty of Veterinary Science, The University of Sydney, New South Wales.
    Objective: To determine the response of Australian cats with lymphosarcoma to chemotherapy and/or surgery in relation to patient and tumour characteristics, haematological and serum biochemical values and retroviral status.

    Design: Prospective study of 61 client-owned cats with naturally-occurring lymphosarcoma subjected to multi-agent chemotherapy and/or surgery.

    Procedure: An accepted chemotherapy protocol utilising l-asparaginase, vincristine, cyclophosphamide, doxorubicin, methotrexate and prednisolone was modified and used to treat 60 cats with lymphosarcoma. Read More
    Response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol: 38 cases (1996-2003).
    J Am Vet Med Assoc 2005 Oct;227(7):1118-22
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0126, USA.
    Objective: To determine response rates and survival times for cats with lymphoma treated with the University of Wisconsin-Madison chemotherapy protocol.

    Design: Retrospective study.

    Animals: 38 cats with lymphoma. Read More
    Treatment and prognostic factors in lymphoma in cats: 103 cases (1977-1981).
    J Am Vet Med Assoc 1989 Mar;194(5):696-702
    Donaldson-Atwood Cancer Clinic, Animal Medical Center, New York, NY 10021.
    The records of 103 cats with lymphoma that underwent chemotherapy were reviewed. Diagnosis was confirmed by cytologic or histopathologic examination of appropriate tissue specimens. Sixty-four cats (62%) had a complete response to chemotherapy (median survival time, 7 months); 21 cats (20%) had a partial response (median survival time, 2. Read More
    Alimentary lymphoma in cats: 28 cases (1988-1993).
    J Am Vet Med Assoc 1995 Dec;207(12):1593-8
    Department of Medicine, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
    Objective: To evaluate response to chemotherapy in cats with alimentary lymphoma and to determine factors associated with survival time.

    Design: Retrospective case series.

    Animals: 28 cats with alimentary lymphoma that underwent chemotherapy. Read More