J Am Acad Dermatol 1998 Oct;39(4 Pt 1):655-7
Department of Dermatology, Medical University of Valladolid, Hospital Clínico Universitario, Spain.
Int J Dermatol 2008 Nov;47 Suppl 1:38-41
Department of Dermatology, and Maastricht University Center for Molecular Dermatology, University Medical Center Maastricht, The Netherlands.
Flegel's disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small, red-brown, hyperkeratotic, papules that are usually located on the lower extremities. The diagnosis is based on the clinical appearance in association with the typical histologic features of orthohyperkeratosis and a subepidermal band-like infiltrate. Treatment is difficult and rarely fully effective. Read More
Am J Dermatopathol 1999 Aug;21(4):395-8
Dermatology 2001 ;202(3):255-8
Department of Dermatology, Eberhard Karl University, Tübingen, Germany.
Hyperkeratosis lenticularis perstans (HLP) or Flegel's disease is a rare dermatosis characterized by asymptomatic hyperkeratotic papules predominantly located on the lower extremities. Lesional and non-lesional epidermis samples were studied by light- and electron-microscopic examination. The main ultrastructural finding was the presence of structurally altered Odland bodies/membrane-coating granules. Read More
Hautarzt 2001 Mar;52(3):231-5
Klinik und Poliklinik für Dermatologie und Venerologie der Universität Rostock, Augustenstrasse 80, 18055 Rostock.
A case report of hyperkeratosis lenticularis perstans (Flegel) is presented. The disease is characterized clinically, histologically and with electron microscope. The evolution of the disease since Flegel described it 40 years ago is considered, with emphasis on etiology, pathogenesis and unanswered questions. Read More