Indian Pediatr 1997 Jan;34(1):20-5
Department of Pediatrics, Maulana Azad Medical College, New Delhi.
Pediatrics 1980 Nov;66(5):693-7
Ten critically ill newborn infants presenting with documented septicemia were treated with antibiotics and supportive measures that included assisted ventilation, large blood transfusions and other volume expanders, sodium bicarbonate, and vasoactive drugs. Upon failure of the above treatment to improve the infants' rapidly deteriorating condition and the development of sclerema, exchange transfusions with fresh whole blood were performed and repeated up to four times. Seven of the ten infants showed immediate improvement and ultimately survived. Read More
Acta Paediatr 1993 Nov;82(11):939-43
Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
Depletion neutropenia caused by overwhelming bacterial infection is associated with fatal outcome and is an objective indicator of the severity of sepsis. Studies on controlled evaluation of exchange transfusion in the management of severe neonatal sepsis have not considered neutropenia as an inclusion criterion, and randomized, controlled trials on evaluation of neutrophil functions after exchange transfusion are scarce. This prompted us to carry out the present study. Read More
Pediatr Infect Dis J 2009 May;28(5):435-8
Department of International Health, International Center for Advancing Neonatal Health, Johns Hopkins University, Baltimore, MD, USA.
Background: This study presents a retrospective analysis of risk factors for sclerema neonatorum in preterm neonates in Bangladesh.
Methods: Preterm neonates admitted to Dhaka Shishu Hospital in Bangladesh were enrolled in a clinical trial to evaluate the effects of topical treatment with skin barrier-enhancing emollients on prevention of sepsis and mortality. Four hundred ninety-seven neonates were enrolled in the study and 51 (10. Read More
Arch Dis Child 1980 Oct;55(10):782-8
C3, factor B, and alpha-1-antitrypsin were determined in newborn infants with septicaemia and sclerema, associated with suspected infections, ABO or Rh incompatibility, and hyperbilirubinaemia of unknown origin, during and after treatment with exchange transfusion. Activation products from C3 and factor B, the clearance of the transfused C3, and its synthesis by the recipient were determined also. Infected newborn infants had low levels of C3 and factor B, but a normal amount of alpha-1-antitrypsin. Read More