Tin-mesoporphyrin inhibits heme oxygenase activity and heme-iron absorption in the intestine.

Pharmacology 1993 Nov;47(5):318-29

Rockefeller University Hospital, New York, NY 10021.

Long-term treatment with the heme oxygenase inhibitor tin-mesoporphyrin produces an iron deficiency anemia in rats analogous to that we reported in patients with the Crigler-Najjar type I syndrome receiving prolonged treatment with the inhibitor to ameliorate severe jaundice [Pediatrics 1992; 89: 175-182]. A dose- and time-dependent inhibition of intestinal heme oxygenase is produced by tin-mesoporphyrin which is independent of iron status of the animal. Tin-mesoporphyrin inhibits the intestinal enzyme whether administered orally or parenterally. Enzyme inhibition by either route results in diminished uptake of 59Fe from radiolabelled heme in the gut. Since tin-mesoporphyrin stimulates excretion of unmetabolized heme into bile its ability to inhibit intestinal heme oxygenase and to decrease heme-iron absorption in the gut probably accounts in part for the iron deficiency produced by the agent. The availability of an orally active agent which inhibits heme oxygenase and heme-iron absorption in the intestine may prove useful for experimental and therapeutic studies in diseases of iron metabolism.

Download full-text PDF

Source
http://dx.doi.org/10.1159/000139113DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
November 1993
3 Reads

Publication Analysis

Top Keywords

heme oxygenase
20
heme-iron absorption
12
absorption intestine
8
intestinal heme
8
iron deficiency
8
tin-mesoporphyrin inhibits
8
inhibits heme
8
heme
7
tin-mesoporphyrin
5
oxygenase
5
route diminished
4
parenterally enzyme
4
orally parenterally
4
enzyme inhibition
4
inhibition route
4
59fe radiolabelled
4
heme gut
4
gut tin-mesoporphyrin
4
radiolabelled heme
4
administered orally
4

Similar Publications