S Gross UMR 8180 CNRS Université de Versailles St Quentin en Yvelines France
Am J Pediatr Hematol Oncol 1994 Nov;16(4):325-8
Department of Pediatrics, College of Medicine, University of Florida, Gainesville 32610-0296.
Purpose: Surgical resection of cervicofacial cystic hygromas and lymphangiomas rarely effects complete reduction because of severe anatomic restrictions.
Patients And Methods: With prior knowledge of cyclophosphamide activity against lesions of this type, a formal trial of cyclophosphamide was initiated.
Results: Overall dose escalation therapy resulted in 50% reduction in mass without recurrence after cessation of therapy and with minimal and readily reversible toxicity.
Conclusions: The favorable responses to cyclophosphamide in this study suggest that a prospective randomized trial should be initiated. Certainly, children who have airway and/or esophageal compromise who have failed surgical therapies should be considered for cyclophosphamide treatment.
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