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Biochim Biophys Acta Mol Cell Biol Lipids 2022 Aug 15:159219. Epub 2022 Aug 15.

Molecular Mechanisms of Cellular Stress and Inflammation, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA. Electronic address:

The endoplasmic reticulum (ER) is an organelle that performs several key functions such as protein synthesis and folding, lipid metabolism and calcium homeostasis. When these functions are disrupted, such as upon protein misfolding, ER stress occurs. ER stress can trigger adaptive responses to restore proper functioning such as activation of the unfolded protein response (UPR). Read More

Harefuah 2022 Aug;161(8):500-505

Obstetrics and Gynecology Department, "Shamir" ("Assaf Harofeh") Medical Center, Tzrifin Israel.

Introduction: Preterm labor involves about 7.4% of live births in Israel and constitutes over 85% of morbidity and mortality in newborns. Risk factors for preterm labor include a history of preterm delivery shortening of the uterine cervix, cervical procedures, uterine malformations, polyhydramnios, intrauterine growth restriction, preeclampsia, multiple gestations, and more. Read More

Front Endocrinol (Lausanne) 2022 1;13:968015. Epub 2022 Aug 1.

Department of Women, Children, and Adolescents, Service of General Pediatrics, Geneva University Hospitals, Geneva, Switzerland.

Scurvy results from a deficiency of ascorbic acid. This disease first appeared in children during the 19th century with the emergence of new dietary habits; in particular, heating milk that leads to a loss of ascorbic acid. Even though scurvy has become a rare condition in western countries, many cases are still reported in pediatric patients, especially in those who lack proper nutrition due to neurological or psychiatric illnesses. Read More

Front Pediatr 2022 1;10:931669. Epub 2022 Aug 1.

Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan.

Background: Thrombotic microangiopathy (TMA) is a syndrome associated with hemolytic anemia, thrombocytopenia, and various organ disorders. Thrombotic thrombocytopenic purpura (TTP) is a disease that develops when a disintegrin-like and metalloproteinase with thrombospondin type l motif 13 (ADAMTS13) activity decreases to < 10% of that in normal plasma, causing platelet thrombosis in microvessels throughout the body. Currently, ADAMTS13-deficient TMA is diagnosed as TTP. Read More

World J Gastroenterol 2022 Jun;28(24):2636-2653

Advanced Translational Diagnostics Laboratory, Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste 34137, Italy.

Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract that have emerged as a growing problem in industrialized countries. Knowledge of IBD pathogenesis is still incomplete, and the most widely-accepted interpretation considers genetic factors, environmental stimuli, uncontrolled immune responses and altered intestinal microbiota composition as determinants of IBD, leading to dysfunction of the intestinal epithelial functions. models commonly used to study the intestinal barrier do not fully reflect the proper intestinal architecture. Read More