The effect of lithium on the iodide concentrating mechanism in mouse salivary gland.

Acta Pharmacol Toxicol (Copenh) 1978 Jul;43(1):55-8

The iodide concentrating mechanism, measured as the gland to plasma (G/P) 125I- concentration ratio, was measured in male mouse submandibular glands after the animals had been fed with varying amounts of lithium chloride for intervals ranging from 0 to 8 weeks. After acute exposure (by injection) to lithium the G/P 125I- fell compared to control values and was further depressed at high serum lithium values. Chronic exposure to lithium was characterised by an increase in the G/P 125I- ratios at therapeutic serum lithium concentrations. It is suggested that lithium has a direct effect on the iodide concentrating mechanism that may be independent of any action of thyroid stimulating hormone during this process. The effect may be important in the formation of lithium induced goitre.

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http://dx.doi.org/10.1111/j.1600-0773.1978.tb02232.xDOI Listing
July 1978
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References

(Supplied by CrossRef)

Bastomsky et al.
1974
Extrathyroidal iodide concentrating mechanisms
Brown-Grant et al.
Physiol. Rev. 1961
Preliminary report of a longitudinal study on the effects of lithium on iodine metabolism
Cooper et al.
Curr. Ther. Res. 1969
Contribution to the mode of action of lithium on iodine metabolism
Cooper et al.
Biol. Psychiat. 1970
Effect of lithium on thyroid function in man
Lazarus et al.
Acta endocr. 1972

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